Plasmacytoid dendritic cells (natural interferon- alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions.

By L. Farkas, K. Beiske, F. Lund-Johansen, P. Brandtzaeg, F. Jahnsen. American Journal of Pathology, 2001

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Type I interferon in systemic lupus erythematosus and other autoimmune diseases. (2006, background): “, 2001), but these cells massively infiltrate inflamed lupus skin (Farkas et al., 2001).”
BDCA-2, a Novel Plasmacytoid Dendritic Cell–specific Type II C-type Lectin, Mediates Antigen Capture and Is a Potent Inhibitor of Interferon α/β Induction (2001, background): “(35) provided strong evidence that PDCs are indeed a major source of IFN- / in SLE.”
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses (2009, background): “Since RNF125 is itself induced by IFN, this again illustrates a manner, in which the initial stimulus activating RLR signaling subsequently triggers production of a factor capable of terminating the response.”
Plasmacytoid predendritic cells initiate psoriasis through interferon-α production (2005, background): “PDCs have also been found in the inflamed tissue of autoimmune diseases, including lupus erythematosus (15), rheumatoid arthritis (41), and psoriasis (17, 19), although a functional relevance had not been demonstrated.”
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood (2003, background): “Finally, our lack of detection of significant IFNtranscripts in the SLE patient’s PBMCs and the reported presence of plasmacytoid DCs in the skin lesions of SLE patients support that this cytokine may be mainly produced in the patient’s tissues (35, 36).”