Choline metabolism in malignant transformation
By K. Glunde, Z. Bhujwalla, S. Ronen. Nature Reviews. Cancer, 2011
774 citations recorded by the source corpus.
Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression. Following transformation, the modulation of enzymes that control anabolic and catabolic pathways causes increased levels of choline-containing precursors and breakdown products of membrane phospholipids. These increased levels are associated with proliferation, and recent studies emphasize the complex reciprocal interactions between oncogenic signalling and choline metabolism. Because choline-containing compounds are detected by non-invasive magnetic resonance spectroscopy (MRS), increased levels of these compounds provide a non-invasive biomarker of transformation, staging and response to therapy. Furthermore, enzymes of choline metabolism, such as choline kinase, present novel targets for image-guided cancer therapy.
Subfields: Cancer Research, Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/44aad5389b7df69094196c3fbbf90c642719d3b4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
Citations in the corpus
- Cellular Fatty Acid Metabolism and Cancer (2013, background): “Many cancers have increased PC levels and increased activity of any of several enzymes in the PC synthesis pathway, while 158 Cell Metabolism 18, August 6, 2013 ª2013 Elsevier Inc. inhibition or knockdown of many of the enzymes decreases cancer phenotypes (Glunde et al., 2011).”