Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network.

By M. Muckenthaler, B. Galy, Matthias W. Hentze. Annual review of nutrition, 2008

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Systemic iron homeostasis. (2013, background): “The complementary but largely separate subject of cellular iron regulation was recently reviewed elsewhere (109, 157).”
Homeostasis and toxicology of essential metals (2012, background): “In Fe-deficient conditions, the IRP/IRE complex is formed (Muckenthaler et al., 2008).”
Regulation of erythropoiesis by hypoxia-inducible factors (2013, background): “binds iron-regulatory protein (IRP) when intracellular iron levels are low.(117) IRPs (IRP1 and IRP2) function as intracellular iron sensors that”
Comprehensive Identification of RNA-Binding Domains in Human Cells (2016, background): “Overall, the RBDpeps identified within metabolic enzymes show that the few well-characterized examples such as aconitase 1 (iron regulatory protein 1, IRP1), glyceraldehyde-3-phophate dehydrogenase, and thymidylate synthase may represent the tip of the iceberg of a more general engagement of metabol”
The Roles of NRF2 in Modulating Cellular Iron Homeostasis (2017, background): “High labile iron pool levels lead to destruction of IRPs through proteasomal degradation, while low labile iron stabilizes them (103, 104, 132, 158, 163).”