Role of JNK activation in apoptosis: A double-edged sword

By Jing Liu, A. Lin. Cell Research, 2005

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The Nerve Growth Factor Signaling and Its Potential as Therapeutic Target for Glaucoma (2014, neutral): “In this review, we will examine the current understanding of the NGF signaling pathway and its potential as a therapeutic target for the treatment of glaucoma.”
Apoptosis, autophagy, necroptosis, and cancer metastasis (2015, background): “However, JNK inhibits apoptosis in IL-3-dependent hematopoietic cells via the phosphorylation and antagonism of the proapoptotic Bcl-2 family protein BAD [66].”
JNK Signaling in Apoptosis (2008, background): “Whether the activation of JNKs leads to cell proliferation or apoptosis is dependent on the stimuli and the cell type involved in such activations (Lin and Dibling, 2002; Liu and Lin, 2005).”
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. (2008, background): “One speculation is that, in metazoans, there is a need that does not exist in unicellular organisms for coordinate regulation of starvation responses and autophagy with other pathways such as cellular proliferation, differentiation, development, inflammation, and apoptosis that are also regulated by”