The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors.

By C. Scharenberg, M. Harkey, B. Torok-Storb. Blood, 2002

804 citations recorded by the source corpus.

Subfields: Hematology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/43ab3259d01d84b3c60d6c5251c4f3d51bd57c07

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hematology

1. J. Aguirre-Ghiso
2. M. Clarke

In Molecular Biology

1. M. Wicha
2. Kyle W. Jackson
3. J. Aguirre-Ghiso
4. J. Foley
5. M. Clarke
6. E. Olson
7. M. Kawamura
8. W. Abdallah

In Oncology

1. M. Wicha
2. G. Dontu
3. M. Clarke
4. J. Aguirre-Ghiso
5. S. Bates
6. E. Olson
7. T. Fojo
8. Ralph J. Deberardinis

Citations in the corpus

• Models, mechanisms and clinical evidence for cancer dormancy (2007, background): “Finally, normal and tumour stem cells express ABC transporters such as ABCG2 (ATP-binding cassette G2”
• Mechanisms of chemoresistance in cancer stem cells (2013, background): “Other drugs, such as paclitaxel, can only be effluxed by MDR1 and not ABCG2 [18,30].”
• Tumour stem cells and drug resistance (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9429"> ABCG2 , but the gene is turned off in most committed progenitor and mature blood cell”
• In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. (2003, background): “It has been shown that the SP fraction of the hematopoietic and neural cells contains the long-term repopulating stem cells (Scharenberg et al. 2002).”
• Plasticity of marrow-derived stem cells. (2003, neutral): “SP cells express the ABCG2 transporter, a transmembrane protein, which allows them to actively exclude Hoechst dye and fluoresce in this very specific manner.(6) SP cells are also present in other tissues including skeletal muscle.”
• Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2) (2003, background): “Bcrp1 was sharply downregulated upon differentiation of murine hematopoietic stem cells into lineage-specific development (Scharenberg et al., 2002).”
• The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche (2010, background): “The ABCG2 transporter is responsible for dye efflux by the side population (SP) stem cells (Goodell et al., 1997; Scharenberg et al., 2002; Zhou et al., 2001).”