Restoration of p53 function leads to tumour regression in vivo

By A. Ventura, D. Kirsch, M. Mclaughlin, D. Tuveson, Jan Grimm, L. Lintault, J. Newman, Elizabeth E. Reczek, Ralph Weissleder, T. Jacks. Nature, 2007

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How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

p21 in cancer: intricate networks and multiple activities (2009, background): “Recent work suggests that tumour regression can be achieved through the reactivation of senescence, for example by restoring p53 functio”
A large intergenic non-coding RNA induced by p53 mediates global gene repression in the p53 response (2010, methodology): “SUPPLEMENTAL INFORMATION Supplemental Information includes Extended Experimental Procedures, six figures, and four tables and can be found with this article online at doi:10.”
Ageing as a risk factor for disease. (2012, background): “The importance of p53 has been underscored by two studies showing that re-activation of p53 in tumours leads to their clearance; however, this was at least partly due to induction of an innate immune response that targeted the tumour cells in vivo [101,102].”
Blinded by the Light: The Growing Complexity of p53. (2009, background): “This approach is elegantly supported by animal studies where reactivation of wild-type p53 leads to efficient tumor regression (Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007).”
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction (2009, neutral): “This concept has been recently demonstrated by reactivation of p53 in mouse tumor models (Martins et al., 2006; Ventura et al., 2007; Xue et al., 2007).”