Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

By Xinyi Guo, Yuanyuan Zhang, Liangtao Zheng, Chunhong Zheng, Jintao Song, Qiming Zhang, Boxi Kang, Zhouzerui Liu, Liang Jin, Rui Xing and 9 more. Nature Medicine, 2018

1,403 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/4331e58b24de4346168b3216fa3cc1400fe76bf8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Ton N. Schumacher
2. Zemin Zhang
3. Yuanyuan Zhang
4. C. Blank

In Molecular Biology

1. Eyal David
2. Zemin Zhang
3. Ido Amit
4. Amos Tanay
5. Adam J. Rubin
6. Cole Trapnell

In Oncology

1. Ton N. Schumacher
2. Zemin Zhang
3. Yuanyuan Zhang
4. C. Blank

Citations in the corpus

• Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma (2020, background): “Natural killer (NK) and T cell clusters included CD4 and CD8 conventional and exhausted T cells, regulatory T cells (Treg), and naive-like T cells (Figure 1D), all bearing resemblance to subsets from prior solid tumor scRNA-seq studies (Guo et al., 2018; Puram et al., 2017; Savas et al., 2018; Tiros”
• The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications (2020, background): “Naive CD8 T cells or CD4 TH cells differentiate into transitional states and finally reach exhausted states, while resting Tregs transit into suppressive states in tumors.(179,181) Such state transitions result in a reduction of effector T cells yet an accumulation of exhausted T cells and suppressi”
• Dysfunctional CD8+ T cells form a proliferative, dynamically regulated compartment within human melanoma (2018, methodology): “…these characteristics of T cell infiltrates would be shared across human cancer types, we performed a comparative analysis with the T cell infiltrates observed in the recently published lung adenocarcinoma dataset of Guo et al., profiling 11,769 QC-positive T cells in 14 samples (Guo et al., 2018).”