Comparison of Proliferative and Multilineage Differentiation Potential of Human Mesenchymal Stem Cells Derived from Umbilical Cord and Bone Marrow

By D. Baksh, R. Yao, Rocky S. Tuan. Stem Cells, 2007

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Burn wound healing and treatment: review and advancements (2015, background): “Apart from bone marrow and adipose tissues, human MSCs can also be isolated from a variety of other tissues such as the amniotic membrane [125], umbilical cord [126, 127], cord blood [128] as well as the hair follicle dermal papilla [129] and sheath [130, 131].”
Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC (2011, background): “Moreover, various papers have been published demonstrating that UC-MSC exhibit a higher proliferation capacity than BM-MSC [46-49].”
The secretion profile of mesenchymal stem cells and potential applications in treating human diseases (2022, background): “Human UC-derived MSCs (MSC(UC)s) exhibit a relatively more stable capacity of proliferation and trilineage differentiation than MSC(BM)s.(22) Compared to MSCs from BM, adipose tissue, or placenta, MSC (UC)s possess the strongest potential to suppress T lymphocyte proliferation by inducing cell-cycle”
The Regulation of Differentiation in Mesenchymal Stem Cells (2010, positive): “Furthermore, data showed that MSCs from different tissues present phenotypic heterogeneity and different growth abilities (Baksh et al. , 2007; Rebelatto et al. , 2008), reﬂecting a tissue speciﬁcity that could be correlated to marked biological and functional differences (De Bari et al. , 2008).”