High cholesterol level is essential for myelin membrane growth

By G. Saher, B. Brügger, Corinna Lappe-Siefke, W. Möbius, R. Tozawa, M. C. Wehr, F. Wieland, S. Ishibashi, K. Nave. Nature Neuroscience, 2005

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Cholesterol metabolism and homeostasis in the brain (2015, positive): “This article is published with open access at Springerlink.com and journal.hep.com.cn 255 rodents takes place when the peak of myelination process occurs, the myelination process is delayed when cholesterol synthesis is deficient (Saher et al., 2005).”
Myelination and the trophic support of long axons (2010, background): “The situation is similar in the PNS of mouse mutants in which Schwann cells cannot synthesize cholestero”
Mechanisms of axon ensheathment and myelin growth (2005, background): “Cholesterol is a major constituent, and mice with oligodendrocytes that lack the ability to synthesize cholesterol show a delay in myelination that seems to be at least partially compensated for by cholesterol uptak”
Axon-glial signaling and the glial support of axon function. (2008, background): “Thus, proteolipids may be required to enrich cholesterol as an essential lipid of myelination (Saher et al. 2005) and to transport other proteins into the myelin compartment efficiently (Werner et al. 2007).”