Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

By D. Muoio, Christopher B. Newgard. Nature reviews. Molecular cell biology, 2008

884 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/42d40b2ed216119845b84a13b63c045a7aa5cc24

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Browning
2. Christopher B. Newgard

In Physiology

1. Christopher B. Newgard
2. Gerald I. Shulman
3. V. Samuel

Citations in the corpus

• Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease (2011, background): “804 Cell Metabolism 14, 804–810, December 7, 2011 ª2011 Elsevier Accumulation of triglyceride (TG) is characteristic of most insulin-resistant tissues (Muoio and Newgard, 2008; Savage et al., 2007).”
• A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance (2009, background): “…of these incompletely oxidized lipid species in muscle mitochondria may contribute to insulin resistance, since two maneuvers that cause their clearance, exercise and transgenic knockout of malonyl CoA decarboxylase, lead to enhanced insulin action (Koves etal., 2008;Muoio and Newgard, 2008).”