The ERBB network: at last, cancer therapy meets systems biology

By Y. Yarden, Gur Pines. Nature Reviews. Cancer, 2012

946 citations recorded by the source corpus.

Subfields: Cancer Research, Computational Theory and Mathematics, Oncology

View Paper: https://www.semanticscholar.org/paper/4290c7cc8caddaedc7a6f7ae017e6395156d38a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Carlos L. Arteaga
2. R. Roskoski

In Computational Theory and Mathematics

1. R. Roskoski

In Oncology

1. Carlos L. Arteaga
2. R. Roskoski
3. J. Engelman

Citations in the corpus

• ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics (2014, background): “Activation of HER2 and EGFR induces transphosphorylation of the ERBB dimer partner and stimulates intracellular pathways such as RAS/RAF/MEK/ERK, PI3K/AKT/TOR, Src kinases, and STAT transcription factors (reviewed in Yarden and Pines, 2012).”
• The ErbB/HER family of protein-tyrosine kinases and cancer. (2014, background): “The PI3K/Akt pathway plays an important role in mediatng cell survival and the Ras/ERK1/2 and PLC pathways participate n cell proliferation [81].”
• Emerging functions of the EGFR in cancer (2017, background): “It is frequently mutated and/or overexpressed in different types of human cancers and is the target of multiple cancer therapies currently adopted in the clinical practice (Yarden and Pines, 2012).”