Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain.

By M. Hemler. Annual Review of Cell and Developmental Biology, 2003

859 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/429049ca329c90382a93e700ab6dd3fd37bceefa

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In Immunology and Allergy

In Molecular Biology

Citations in the corpus

The tetraspanin web modulates immune-signalling complexes (2005, background): “, fungi (but not yeast), Caenorhabditis elegans , insects, zebrafish and mammal”
Extracellular vesicles: Exosomes, microvesicles, and friends (2013, background): “These include tetraspanins, a family of >30 proteins that are composed of four transmembrane domains (Hemler, 2003).”
Exosomes: a common pathway for a specialized function. (2006, background): “Due to their affinity for cholesterol and sphingolipids, they form membranous microdomains involved in adhesion, motility or signaling (37).”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “Cell Mol Life Sci (2011) 68(19):3275–92.”
Biogenesis and function of multivesicular bodies. (2007, background): “Tetraspanins can homoand hetero-oligomerize into complex webs or tetraspanin-enriched microdomains (TEMs), which also appear to connect with the actin cytoskeletal machinery and gather cholesterol (Charrin et al. 2003, Delaguillaumie et al. 2004, Hemler 2003, Silvie et al. 2006).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Similarly, exosomal tetraspanin complexes are also involved in target cell selection in vitro and in vivo [23], possibly by modulating integrins [24].”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “These include integrin associations with one or another RTK, with specific tetraspanins, syndecans, uPAR, CD44, and direct integrin recruitment of signaling components (Cantor et al., 2008; Danen and Yamada, 2001; Hemler, 2003; Kugler et al., 2003; Morgan et al., 2007).”