The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality.

By P. Taylor, C. Lees, B. Blazar. Blood, 2002

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Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans (2006, background): “Due to the relative simplicity of obtaining large numbers of purified CD4CD25 Tregs by selection for high levels of CD25 expression (89, 90, 226), the poten-”
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival (2004, background): “Discussion Emerging evidence suggests that T reg cells, particularly CD4 + CD25 + T reg cells, are key mediators of peripheral toleranc”
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. (2011, background): “Although ex vivo expanded polyclonal (11) or recipient-specific Tregs (12) were proposed to circumvent this potential barrier, we opted for closed, automated immunoselection (13) of naturally occurring Tregs.”
Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells1 (2004, background): “Removal of CD4 CD25 T cells present in the graft dramatically accelerates GVHD, whereas the addition of either freshly isolated or in vitro expanded CD4 CD25 donor Treg cells significantly delays or prevents GVHD (58, 60–62).”