PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization.

By M. Houslay, D. Adams. Biochemical Journal, 2003

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PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005, background): “Phosphorylation of PDE4D3 and PDE4D5 is known to contribute to cAMP homeostasis and cAMP signaling at a specialized region in the cell through their interaction with the complex of the A-kinase anchoring protein (AKAP) and PKA (115, 250, 411).”
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. (2005, methodology): “A: Control (n 9); B: VP (n 10); C: GLP-1 (n 13); D: exendin (9-39) and GLP-1 (n 6); E: Rp-cAMP and GLP-1 (n 6); F: LY294002 and GLP-1 (n 6); and G: UO126 and GLP-1 (n 6).”
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use (2006, background): “In the case of PDE4A1, it is thought that a hydrophobic sequence in the N terminus can be inserted into the lipid bilayer in a calcium- and phosphatidic acid-specific manner (Houslay and Adams, 2003).”
RACK1, A multifaceted scaffolding protein: Structure and function (2011, positive): “Specifically, cAMP is hydrolysed through the action of cAMP phosphodiesterases (PDEs) [108], and RACK1 interacts with phosphodiesterase isoform PDE4D5 [107,109,110].”