Circulating levels of IGF-1 directly regulate bone growth and density.
By S. Yakar, C. Rosen, W. Beamer, C. Ackert-Bicknell, Yiping Wu, Jun-li Liu, G. Ooi, Jennifer Setser, J. Frystyk, Y. Boisclair and 1 more. Journal of Clinical Investigation, 2002
982 citations recorded by the source corpus.
Subfields: Cancer Research, Endocrinology, Diabetes and Metabolism, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/425b15d68bdf7196bb510c00cffe4f0d7e1cf571
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
In Endocrinology, Diabetes and Metabolism
In Molecular Biology
Citations in the corpus
- Growth hormone, insulin-like growth factors, and the skeleton. (2008, background): “Systemic and local skeletal IGF-I play a role in bone formation and the maintenance of bone mass (16).”
- Gut microbiota induce IGF-1 and promote bone formation and growth (2016, background): “Circulating IGF-1 is mainly produced by the liver (33).”
- Skeletal remodeling in health and disease (2007, background): “There is an epidemiological and genetic correlation between bone mass and serum IGF-1, rather than between bone mass and serum growth hormon”
- Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Insulin-like growth factor 1 (IGF-1) has been shown to have a positive effect on bone formation (170).”