Three dimensional optical angiography.

By Ruikang K. Wang, S. Jacques, Zhenhe Ma, Sawan Hurst, S. Hanson, A. Gruber. Optics Express, 2007

656 citations recorded by the source corpus.

With existing optical imaging techniques three-dimensional (3-D) mapping of microvascular perfusion within tissue beds is severely limited by the efficient scattering and absorption of light by tissue. To overcome these limitations we have developed a method of optical angiography (OAG) that can generate 3-D angiograms within millimeter tissue depths by analyzing the endogenous optical scattering signal from an illuminated sample. The technique effectively separates the moving and static scattering elements within tissue to achieve high resolution images of blood flow, mapped into the 3-D optically sectioned tissue beds, at speeds that allow for perfusion assessment in vivo. Its development has its origin in Fourier domain optical coherence tomography. We used OAG to visualize the cerebral microcirculation, of adult living mice through the intact cranium, measurements which would be difficult, if not impossible, with other optical imaging techniques.

Subfields: Biomedical Engineering, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/422194625eb23f366be756f41dc94df1244cde2f

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In Biomedical Engineering

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Split-spectrum amplitude-decorrelation angiography with optical coherence tomography (2012, methodology): “OMAG works by using a modified Hilbert transform to separate the scattering signals from static and moving scatters [26].”
Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye (2015, neutral): “Invest Ophthalmol Vis Sci 52(3):1606–1612.”
Optical coherence tomography angiography (2017, positive): “…method, known as Optical Microangiography (also commonly called OMAG) addressed the problem of bulk eye motion by modifying OCT hardware to introduce a modulation or externally imposed phase variation which improved the differentiation between stationary tissue and blood flow (Wang et al., 2007a).”
Optical Coherence Tomography Angiography (2016, methodology): “Doppler OCT uses the Doppler phase shift to quantify blood flow in larger vessels and measure total retinal blood flow,(5) an application that we will not review, while OCTA is more concerned about separating moving scatters from static background tissue to create angiograms.(6)”