Priming of Centromere for CENP-A Recruitment by Human hMis18α, hMis18β, and M18BP1

By Yohta Fujita, Takeshi Hayashi, Tomomi Kiyomitsu, Y. Toyoda, Aya Kokubu, C. Obuse, M. Yanagida. 2007

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Propagation of centromeric chromatin requires exit from mitosis (2007, background): “The recently identifi ed hMis18α, hMis18β, and M18BP1/hsKNL2 proteins, of which the M18BP1/hsKNL2 Myb domain–containing protein is an evolutionary conserved component, have been proposed to be required for CENP-A loading (Fujita et al., 2007; see Maddox et al. on p. 757 of this issue).”
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (2009, positive): “While the human hMis18 complex is required for CENP-A association with centromeres, it does not interact with CENP-A,andlikein S.pombe itisthoughttopreparecentromeres to accept CENP-A by altering histone acetylation (Fujita et al., 2007; Maddox et al., 2007).”
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP. (2009, positive): “…complex is recruited to centromeres beginning in late anaphase and persists for approximately 3 hr 476 Cell 137, 472–484, May 1, 2009 ª2009 Elsevier Inc. after metaphase, which overlaps with the time during which new CENP-A is recruited to centromeres (Fujita et al., 2007; Jansen et al., 2007).”