An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performance.

By Gary S. Aston-Jones, J. Cohen. Annual Review of Neuroscience, 2005

4,217 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/41f5caf540db98743f93ef7cd223b2155bdeff47

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Citations in the corpus

Relationships between pupil diameter and neuronal activity in the locus coeruleus, colliculi, and cingulate cortex (2015, background): “…can enhance both excitatory and inhibitory effects of incoming signals on targeted neurons, thus serving as a modulator of overall neural gain (ServanSchreiber et al., 1990; Eldar et al., 2013; Aston-Jones and Cohen, 2005; Waterhouse et al., 1980; Segal and Bloom, 1976; Dillier et al., 1978).”
Pupil Diameter Predicts Changes in the Exploration–Exploitation Trade-off: Evidence for the Adaptive Gain Theory (2011, methodology): “A second assumption of the theory is that transitions between the phasic and tonic LC modes and corresponding control states are driven by online assessments of task-related utility carried out in ventral and medial frontal structures (Aston-Jones & Cohen, 2005).”
Modafinil: A Review of Neurochemical Actions and Effects on Cognition (2008, methodology): “Importantly, modafinil also augments pupillary dilation parameters (Hou et al, 2005) in a manner consistent with LC phasic responses to task-relevant events (Beatty, 1982a, b; Richer and Beatty, 1987), suggesting the potential for LC/NE system effects in optimizing cognitive task performance, as des”
The expected value of control: An integrative theory of anterior cingulate cortex function (2013, positive): “Taken together, these findings provide support for the role of dACC in specifying adaptive adjustments in threshold that are then implemented by STN. Similarly, Aston-Jones and Cohen (2005) have proposed that dACC is involved in monitoring behavioral outcomes and deciding when it is appropriate to e”
How do emotion and motivation direct executive control? (2009, result): “[ 51 ]). These and other findings have led to the suggestion that the LC is responsive to ongoing evaluations of task utility provided by input from frontal structures [51].”
Rational regulation of learning dynamics by pupil–linked arousal systems (2012, methodology): “Consistent with our model, in which noise is only used to compute change-point probability (equations (5) and (6)), these manipulations of noise were reflected in pupil change, but only insofar as pupil change represented change-point probability (Fig.”
Adaptive gain and the role of the locus coeruleus–norepinephrine system in optimal performance (2005, background): “(See Usher et al., 1999; Aston-Jones et al., 2000; Aston-Jones and Cohen, 2005, for more details and discussion of this model.)”
An opportunity cost model of subjective effort and task performance (2013, positive): “Aston-Jones and Cohen (2005) proposed a similar idea, arguing that norepinephrine rather than dopamine provides the critical signal regarding the benefit of continued engagement.”
Surprise signals in anterior cingulate cortex: Neuronal encoding of unsigned reward prediction errors driving adjustment in behavior (2011, background): “Norepinephrine (NE) neurons also signal unexpected and attentionally salient events (Aston-Jones et al., 1986, 1994, 1997; Aston-Jones and Cohen, 2005).”
The roles of the amygdala in the affective regulation of body, brain, and behaviour (2010, background): “Amg modulates the production of NE through LC, which innervates virtually the whole cortex, BG, Th, Hyp, Hip, CB, and the spinal cord (Berridge and Waterhouse 2003 ; Aston, Jones, and Cohen 2005 ).”