A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

By M. Tatar, A. Kopelman, D. Epstein, M. Tu, C. Yin, R. Garofalo. Science, 2001

1,646 citations recorded by the source corpus.

Subfields: Aging, Cellular and Molecular Neuroscience, Endocrine and Autonomic Systems

View Paper: https://www.semanticscholar.org/paper/40b68abdb52d7227742b3d23fe809f384d608605

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. V. Longo
2. G. Lithgow
3. Rute Martins
4. W. Link
5. Hannah J. Zhang
6. K. Kregel
7. J. Speakman
8. C. Kenyon

In Cellular and Molecular Neuroscience

1. D. Hahn
2. C. Kenyon
3. D. Denlinger
4. J. Speakman
5. V. Longo
6. K. Tougeron

In Endocrine and Autonomic Systems

1. V. Longo
2. G. Lithgow
3. Rute Martins
4. W. Link
5. Hannah J. Zhang
6. K. Kregel
7. C. Kenyon
8. J. Speakman

Citations in the corpus

• Life and death: metabolic rate, membrane composition, and life span of animals. (2007, neutral): “Thus neither the rate-of-living nor antioxidant defenses appear to explain longevity differences in these Drosophila lines.”
• Nuclear receptors — a perspective from Drosophila (2005, background): “Interestingly, JH titres have also been linked to the longevity of the adult fly, mediated by insulin signallin”
• An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “Not surprisingly, life-extension in these animals is generally accompanied by increased antioxidant defenses and resistance to oxidative stress (15, 103, 144, 258, 271).”
• Modulation of mammalian life span by the short isoform of p53. (2004, background): “In Drosophila melanogaster, some allelic combinations of the INS/IGF-R produce flies with extended life span (Clancy et al. 2001; Tatar et al. 2001).”
• Meeting the energetic demands of insect diapause: nutrient storage and utilization. (2007, background): “For example, adults carrying weak null alleles for the Drosophila insulin receptor have small somatic body sizes, hypertrophied fat bodies with high lipid stores, and are sub-reproductive and long-lived, like flies in an adult reproductive diapause (Tatar et al., 2001).”
• Evolutionary Endocrinology: The Developing Synthesis between Endocrinology and Evolutionary Genetics (2007, background): “Researchers identified associations between Mc1r DNA sequence and body-color phenotype in some field populations of mice and lizards (Nachman et al. 2003, Rosenblum et al. 2004) and in several bird species (Mundy et al. 2003, Theron et al. 2001).”