Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

By T. Le Roy, M. Llopis, P. Lepage, A. Bruneau, S. Rabot, C. Bevilacqua, Patrice Martin, C. Philippe, Francine Walker, A. Bado and 3 more. Gut, 2012

916 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/408e0b9807fb27fdc30d11ccea6d0c421584ffff

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Lan Lin
2. A. Diehl
3. Jianqiong Zhang

In Molecular Biology

1. Lan Lin
2. Kyongbum Lee
3. J. Rawls
4. Lawrence A. David
5. Liping Zhao
6. Jianqiong Zhang
7. M. Derrien
8. Patrice D Cani

In Physiology

1. J. Rawls
2. Liping Zhao

Citations in the corpus

• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “Taken together, changes in the gut microbiota-host interaction derived from the impairment in NLRP3 and NLRP6 inflammasome sensing, may govern the propensity for development of multiple metabolic syndrome-associated abnormalities such as NAFLDNASH progression [168].”
• Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. (2015, positive): “In addition, ileal and serum C16:0, C18:0, respective donor mice, thus implicating gut bacterial composition in hepatic lipid accumulation (25).”
• The severity of NAFLD is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota (2016, background): “Indeed, by manipulating the gut microbiota, animal studies have demonstrated direct roles for gut microbiota in each of the liver lesions observed in NAFLD: steatosis,((28)), NASH,((29)) fibrosis,((30)) and liver cancer.”
• Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages (2018, positive): “Germ-free (GF) mice fed a high-fat diet (HFD) and inoculated with bacterial isolates from feces of hyperglycemic mice developed steatohepatitis, whereas GF mice fed the same HFD but inoculated with bacteria from normoglycemic mice only showed mild steatosis (Le Roy et al., 2013).”
• Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice (2014, background): “…one or more key phylotypes of Bifidobacterium, Olsenella, Barnesiella, Allobaculum and Butyrivibrio that were previously associated with alleviated MS or were shown to prevent dextran sulfate sodium-induced inflammation (Ohkawara et al., 2006; Zhang et al., 2010, 2012b; Le Roy et al., 2012).”