Defective valvulogenesis in HB‐EGF and TACE‐null mice is associated with aberrant BMP signaling

By L. F. Jackson, T. Qiu, S. Sunnarborg, Aileen Chang, Chunlian Zhang, C. Patterson, David C. Lee. 2003

448 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Hematology, Molecular Biology

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In Hematology

1. D. Edwards
2. C. A. Dinarello

In Molecular Biology

1. D. Edwards
2. S. Eguchi
3. H. Ohtsu
4. P. Dempsey
5. M. Handsley
6. C. Pennington
7. R. Baron
8. P. Saftig

Citations in the corpus

• The ADAM metalloproteinases (2008, background): “In particular, HB-EGFÀ/À mice die before weaning with defects in valvulogenesis in the heart and hypoplastic, poorly differentiated lungs that parallel those seen in Adam17À/À mice (Jackson et al., 2003; Shi et al., 2003; Zhao et al., 2001 ).”
• Essential Role for ADAM19 in Cardiovascular Morphogenesis (2004, background): “Recent studies have demonstrated that mice lacking HBEGF also have thickened aortic and pulmonic valves (19, 20).”
• ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. (2006, background): “These include defects in branching morphogenesis of the lung (116), thickened and misshapen heart valves that resemble those of mice lacking HB-EGF (49), and regulation of amphiregulin-dependent mammary gland mor-”
• ADAMs: key components in EGFR signalling and development (2005, background): “, thickened and misshapen heart valves that resemble those of mice lacking HB-EG”
• Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands (2004, background): “Mice lacking ADAM17 die perinatally and resemble mice lacking TGF (Mann et al., 1993), HB-EGF (Iwamoto et al., 2003; Jackson et al., 2003), and the EGFR (Miettinen et al., 1995; Sibilia and Wagner, 1995; Threadgill et al., 1995; Peschon et al., 1998).”
• Essential roles of Meltrin β (ADAM19) in heart development (2004, background): “Recent studies indicate that HB-EGF is expressed in the endocardial epithelia, and participates in the formation of heart valves (Iwamoto et al., 2003; Jackson et al., 2003).”
• Metalloprotease‐disintegrin ADAM8: Expression analysis and targeted deletion in mice (2005, background): “…processes, including sperm–egg interactions, neurogenesis, neovascularization, and heart development (Black and White, 1998; Schlöndorff and Blobel, 1999; Primakoff and Myles, 2000; Horiuchi et al., 2003; Jackson et al., 2003; Seals and Courtneidge, 2003; Kurohara et al., 2004; Zhou et al., 2004).”
• Deficits in spatial learning and motor coordination in ADAM11-deficient mice (2006, background): “For example, ADAM10, ADAM17 and ADAM19 are critical for normal development by providing growth signals at the correct times and places [3-6].”