A Disintegrin and Metalloprotease (ADAM): Historical Overview of Their Functions
By Nives Giebeler, P. Zigrino. 2016
144 citations recorded by the source corpus.
Since the discovery of the first disintegrin protein from snake venom and the following identification of a mammalian membrane-anchored metalloprotease-disintegrin implicated in fertilization, almost three decades of studies have identified additional members of these families and several biochemical mechanisms regulating their expression and activity in the cell. Most importantly, new in vivo functions have been recognized for these proteins including cell partitioning during development, modulation of inflammatory reactions, and development of cancers. In this review, we will overview the a disintegrin and metalloprotease (ADAM) family of proteases highlighting some of the major research achievements in the analysis of ADAMs’ function that have underscored the importance of these proteins in physiological and pathological processes over the years.
Subfields: Genetics, Immunology and Allergy, Molecular Biology
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Citations in the corpus
- A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “In 2006, the crystal structure of Vascular Adhesion Protein-1 (VAP1) was revealed and helped to decipher the ADAMs’ MDC domain architecture and their unique activity sites [8].”