Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity

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CircRNA: a novel type of biomarker for cancer (2017, background): “Similarly, circFoxo3 decreases MDM2-induced Foxo3 ubiquitination and degradation, which leads to increasing Foxo3 expression that serves as a trigger for apoptosis by up-regulating the expression of Puma gene [67, 68].”
Non-coding RNAs in disease: from mechanisms to therapeutics (2023, positive): “…of their mRNA targets 76 . circRNAs can also function as protein ‘enhancers’, by forming a circRNA–protein complex 77 , acting as protein scaffolds 78 , or recruiting proteins to a specific loci or subcellular compartment that facilitates their co-localization and thereby influences…”
CircRNA: functions and properties of a novel potential biomarker for cancer (2017, background): “More circRNA functions were also found, such as acting as scaffolds in the assembly of protein complexes [3], sequestering proteins from their native subcellular localization [4], modulating the expression of parental genes [5–8], regulating alternative splicing [9] and RNA–protein interactions [10]”
Circular RNA-protein interactions: functions, mechanisms, and identification (2020, background): “circFOXO3 MDM2,P53 induces apoptosis breast cancer cell cytoplasm [45]”
Circular RNA: metabolism, functions and interactions with proteins (2020, background): “This also occupies MDM2 and relieves Foxo3 ubiquitination [92].”