Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

By Gabriela Bindea, Bernhard Mlecnik, M. Tosolini, A. Kirilovsky, M. Waldner, A. Obenauf, H. Angell, T. Fredriksen, Lucie Lafontaine, A. Berger and 7 more. Immunity, 2013

3,752 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/4046b22cdf4b179dd3753d4cf246c99f8ea8ba18

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Citations in the corpus

Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets (2019, background): “Compared to a pan-macrophage immune signature (Bindea et al., 2013; Tamborero et al., 2018), the TAM signature was associated with shorter disease-specific survival in the METABRIC cohort.”
Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “Recent studies of immunophenotypes in CRC have shown that the immune cell density is higher at the tumor invasive margin than in the tumor center (Bindea et al., 2013; Mlecnik et al., 2016).”
Molecular and genetic properties of tumors associated with local immune cytolytic activity (2015, neutral): “In addition, it was also associated with interferon-stimulated chemokines (CXCL9, CLCL10, and CXCL11) that attract T cells, as observed previously (Bindea et al., 2013).”
The Immune Landscape of Cancer (2018, background): “Characterization of the immune microenvironment using gene expression signatures, T cell receptor (TCR), and B cell receptor (BCR) repertoire, and analyses to identify neo-antigenic immune targets provide a wealth of information in many cancer types and have prognostic value (Bindea et al., 2013; Br”
Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas. (2017, positive): “To better define the immune cell infiltrates, we assigned each sarcoma type an immune infiltration score for various immune cells based on their gene expression signatures (Bindea et al., 2013) (Figure 7B).”
Cooperation between Constitutive and Inducible Chemokines Enables T-cell Engraftment and Immune Attack in Solid Tumors (2019, methodology): “The signature scores for the immune subsets taken from Bindea et al (Bindea et al., 2013) were computed as the median of the expression of the genes used to define each subset.”
Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer (2017, neutral): “Three immune cell subgroups were identiﬁed by non-negative factorization clustering 60 from 175 non-tumour cells using 412 genes annotated in 11 non-overlapping immune cell types 37 (Supplementary Table 3).”