Neuroinflammation in Parkinson's disease: a target for neuroprotection?

By E. Hirsch, S. Hunot. Lancet Neurology, 2009

1,866 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/4038af0dce960396bddc7b9e478049208ebfd82f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Christopher K. Glass
2. Kaoru Saijo
3. C. Cunningham

In Neurology

1. L. Volpicelli-Daley
2. Christopher K. Glass
3. Kaoru Saijo
4. C. Cunningham

Citations in the corpus

• Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction (2023, background): “Inflammatory mediators, such as reactive oxygen species (ROS), nitric oxide (NO), tumor necrosis factor (TNF)-alpha(α), and interleukin (IL)-1beta(β), derived from non-neuronal cells, are known to modulate the progression of neuronal cell death in PD [59, 60] (Fig.”
• Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease (2011, background): “It is also well established that inflammation and proinflammatory cytokines like IL-1b, IL-6 and TNF-a are one major source of tissue oxidative stress [30].”
• Complexity of dopamine metabolism (2013, background): “Therefore, we refer to other reviews that nicely summarize this topic [175-178].”
• Microglial cell origin and phenotypes in health and disease (2011, background): “In addition, signs of inflammation, such as microglial cell activation and astrogliosis , as well as increased levels of pro-inflammatory mediators in the serum and cerebral spinal fluid, are often observed in patients with Parkinson's disease and in animal models of the diseas”
• Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “Inflammation-Dependent Pathology Several lines of evidence suggest that inflammatory mediators such as ROS, NO, TNF-a, and interleukin (IL)-1b derived from non-neuronal cells including microglia modulate the progression of neuronal cell death in PD (Hirsch and Hunot, 2009) (Figure 2).”
• Microglia and neurodegeneration: The role of systemic inflammation (2013, background): “It is significant that these models still provide the most unambiguous evidence of M1 microglial phenotypes and of a disease course that is amenable to anti-inflammatory treatment (Hirsch and Hunot, 2009).”