Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycation.

By Paul J Thornalley. Biochemical Society Transactions, 2003

620 citations recorded by the source corpus.

Subfields: Applied Microbiology and Biotechnology, Clinical Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/401a9cc1aad1b5f090d47f4728ce33c67324208a

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In Molecular Biology

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Citations in the corpus

• Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. (2005, background): “For example, glyoxalase I, a cytosolic enzyme that functions to decrease glycation reactions, displays decreased activity with aging (Thornalley, 2003).”
• Exogenous nitric oxide alleviates high temperature induced oxidative stress in wheat (Triticum aestivum L.) seedlings by modulating the antioxidant defense and glyoxalase system (2012, background): “Firstly, Gly I catalyzes the isomerization of the spontaneously formed hemithioacetal adduct between GSH and 2-oxoaldehydes (such as MG) into S-2hydroxyacylglutathione (Creighton and Hamilton, 2001; Thornalley, 2003).”