Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines.

By K. Agwuh, A. Macgowan. Journal of Antimicrobial Chemotherapy, 2006

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Minocycline: far beyond an antibiotic (2013, background): “(2009) reported that minocycline, at concentrations similar to those obtained therapeutically in serum (5 or 10 mM) (Agwuh and MacGowan, 2006), reduced the protease-activated receptor 2-mediated production of IL-8, and thus attenuated the proinflammatory process in epidermal keratinocytes.”
Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions (2012, background): “9 g/ml, while those attained in the urine and in the epithelial lining fluid are severalfold lower (2, 36, 88, 210).”
Penetration of Drugs through the Blood-Cerebrospinal Fluid/Blood-Brain Barrier for Treatment of Central Nervous System Infections (2010, background): “Its protein binding is 80%, and its elimination half-life is long, ranging from 12 to 25 h (1).”