Drug discovery in the ubiquitin–proteasome system

By G. Nalepa, M. Rolfe, J. Harper. Nature reviews. Drug discovery, 2006

604 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/3fbdb71a371b152b262f92ffacad2ab2b16f06ed

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Wenyi Wei
2. Lei Chen
3. T. Meng
4. Ping Wang
5. Lu Deng

Citations in the corpus

• The role of ubiquitination in tumorigenesis and targeted drug discovery (2020, background): “β-TrCP1 can ubiquitinate the phosphorylated inhibitor of nuclear factor-κB (IκB) and lead to its degradation by the proteasomal pathway.(402,403) A small phosphopeptide agonist has been designed to target the IκB Ub ligase, and this peptide can inhibit IκB degradation in TNF-stimulated HeLa cells.”