Noise in Gene Expression Determines Cell Fate in Bacillus subtilis

By H. Maamar, Arjun Raj, D. Dubnau. Science, 2007

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Bistability, epigenetics, and bet-hedging in bacteria. (2008, background): “When cells divide, not only DNA but also cellular factors such as proteins offspring.”
Stochastic gene expression and its consequences (2008, methodology): “…et al., 2000; Isaacs et al., 2003; Kramer and Fussenegger, 2005) and also in several naturally occurring genetic positive feedback loops (Acar et al., 2005; Maamar and Dubnau, 2005; Maamar et al., 2007; Suel Cell 135, October 17, 2008 ©2008 Elsevier Inc. 221 et al., 2006, 2007; Smits et al., 2005).”
Stochasticity and Cell Fate (2008, background): “The green fluorescence reveals the subpopulation of cells that are ON for ComK.”
Cellular Decision-Making and Biological Noise: From Microbes to Mammals (2011, background): “The crucial role of noise in competence initiation was independently confirmed by another group (Maamar et al., 2007) after successfully decoupling ComK protein expression noise and mean.”
Single-cell RNA sequencing technologies and bioinformatics pipelines (2018, background): “Increasing evidence further suggests that gene expression is heterogeneous, even in similar cell types 1 – 3 ; and this stochastic expression re ﬂ ects cell type composition and can also trigger cell fate decisions 4,5 .”