Quinolone antibiotics induce Shiga toxin-encoding bacteriophages, toxin production, and death in mice.

By Xiaoping Zhang, Aaron D. McDaniel, L. Wolf, G. Keusch, M. Waldor, D. Acheson. Journal of Infectious Diseases, 2000

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Mechanisms and consequences of intestinal dysbiosis (2017, background): “In addition to a sudden change in the abundance of some bacterial taxa, the lytic action of bacteriophages liberates intracellular toxins [175] as well as cell wall fragments, lipids and nucleic acids, which are recognized as pathogen-associated molecular patterns activating innate immunity.”
Recent Advances in Understanding Enteric Pathogenic Escherichia coli (2013, background): “The hemorrhagic coli pilus (HCP) is a type IV pilus found in STEC O157:H7 that forms long bundled fibers that are able to attach to extracellular matrix proteins on epithelial cells (308, 309).”
Practice guidelines for the management of infectious diarrhea. (2001, background): “effects of antibiotic treatment of STEC infections [47, 140].”
Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “For instance, the fluoroquinolone-mediated SOS response may trigger expression, excision, and transfer of prophage genes (176).”
Disease-specific Alterations in the Enteric Virome in Inflammatory Bowel Disease (2015, background): “However, environmental stimuli, such as nitric oxide and antibiotics, induce the production of infectious bacteriophages that lyse their bacterial host and infect neighboring cells bearing specific receptors (Lindsay et al., 1998; Maiques et al., 2006; Zhang et al., 2000; Zhang and LeJeune, 2008).”