Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide.

By J. Steiner, H. Bielau, R. Brisch, P. Danos, O. Ullrich, C. Mawrin, H. Bernstein, B. Bogerts. Journal of Psychiatric Research, 2008

764 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Neurology, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/3f4dad01fbb011b8702f40956d75d8ead83f301b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. Andrew H. Miller
2. Charles L Raison
3. C. Nemeroff
4. Eléonore Beurel
5. M. Toups
6. E. Haroon
7. F. Lotrich
8. J. Felger

In Neurology

1. Andrew H. Miller
2. Charles L Raison
3. E. Haroon
4. C. Nemeroff
5. Eléonore Beurel
6. R. Yirmiya
7. M. Toups

In Psychiatry and Mental health

1. Andrew H. Miller
2. Charles L Raison

Citations in the corpus

• Inflammatory Cytokines in Depression: Neurobiological Mechanisms and Therapeutic Implications (2013, background): “These finding suggest that neuroactive KYN metabolites, KA and QUIN, are likely responsible for many behavioral changes associated with cytokine-induced IDO activity, and may involve effects on other neurotransmitter systems (see Section 3.3 for discussion).”
• Psychoneuroimmunology Meets Neuropsychopharmacology: Translational Implications of the Impact of Inflammation on Behavior (2012, background): “Thus, data that acute and chronic psychosocial stress can activate the inflammatory response represent a major breakthrough in the link between stress and depression as it relates to the immune system.”
• Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression (2009, neutral): “Of further relevance to the activation of inflammatory pathways within clinical populations are recent postmortem data suggesting that suicide is associated with increased microglia in the prefrontal cortex (86).”
• A Randomized Controlled Trial of the Tumor Necrosis Factor-alpha Antagonist Infliximab in Treatment Resistant Depression: Role of Baseline Inflammatory Biomarkers (2013, neutral): “(%) 13 (43) 19 (63) Bipolar disorder, No.”
• Depression as a microglial disease. (2015, background): “In contrast to depression per se, suicide (committed by psychiatric or non-psychiatric individuals) was associated with microglial priming and activation as well as elevated density of perivascular macrophages around blood vessels ([32,33], but see [34]).”
• The Bidirectional Relationship of Depression and Inflammation: Double Trouble (2020, background): “, 2014), as well as increased microglial priming and activation (Steiner et al., 2008), whether or not they exhibit psychiatric symptoms.”