In search of the tumour-suppressor functions of BRCA1 and BRCA2

By R. Scully, D. Livingston. Nature, 2000

661 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/3f4500b084cc09bebc27646d2d718c0567739ae2

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Citations in the corpus

Involvement of Brca1 in S-Phase and G2-Phase Checkpoints after Ionizing Irradiation (2001, background): “Accumulated data have demonstrated an important role for Brca1 in cellular responses to IR (20); however, conflicting conclusions have been drawn about whether Brca1 plays a direct role in cell cycle checkpoints.”
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex (2002, background): “The interaction between BRCA2 and RAD51 is critical for the biological functions of both molecule”
Cell cycle checkpoint signaling through the ATM and ATR kinases. (2001, background): “Like the NBS1 complex, BRCA1 participates in both checkpoint and repair pathways in DNA-damaged cells (Scully and Livingston 2000; Scully et al. 2000; Xu et al. 2001).”
X chromosomal abnormalities in basal-like human breast cancer. (2006, background): “BRCA1 operates in the maintenance of genomic integrity, chromatin remodeling, transcription regulation, and cell cycle checkpoint control (Scully and Livingston, 2000; Venkitaraman, 2002).”
Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention (2017, background): “Impairment of homologous recombination is one means by which BRCA1 loss promotes carcinogenesis; however, there are other functions of BRCA1 that are less understood (7).”
The emerging genetic and molecular basis of Fanconi anaemia (2001, background): “However, despite intensive research into the function of BRCA1, it remains unclear as to what this protein does upon DNA damag”
A Guide for Functional Analysis of BRCA1 Variants of Uncertain Significance (VUS) (2012, background): “BRCA1 plays a key role in maintaining genome integrity in response to DNA DSBs arising during DNA replication or exogenous insults [Dapic and Monteiro, 2006; Narod and Foulkes, 2004; Scully and Livingston, 2000].”
Zinc and human health: an update (2011, positive): “The familial breast and ovarian cancer susceptibility gene BRCA1 encodes a protein of 1863 amino acids (Scully and Livingston 2000).”
BRCA1 and BRCA2: 1994 and beyond (2004, background): “These complex issues have been discussed in detail in several review”
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling (2005, background): “…coupled repair, cell cycle checkpoint control, centrosome duplication, transcription regulation, DNA damage signaling, growth regulation and the induction of apoptosis (Xu et al., 1999; Scully, 2000; Scully and Livingston, 2000; Kerr and Ashworth, 2001; Pierce et al., 2001; Venkitaraman, 2001).”