REM Sleep Behavior Disorder: Updated Review of the Core Features, the RBD-Neurodegenerative Disease Association, Evolving Concepts, Controversies, and Future Directions

By Brad Boeve. Annals of the New York Academy of Sciences, 2010

638 citations recorded by the source corpus.

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia manifested by vivid, often frightening dreams associated with simple or complex motor behavior during REM sleep. The polysomnographic features of RBD include increased electromyographic tone +/− dream enactment behavior during REM sleep. Management with counseling and pharmacologic measures is usually straightforward and effective. In this review, the terminology, clinical and polysomnographic features, demographic and epidemiologic features, diagnostic criteria, differential diagnosis, and management strategies are discussed. Recent data on the suspected pathophysiologic mechanisms of RBD are also reviewed. The literature and our institutional experience on RBD are next discussed, with an emphasis on the RBD–neurodegenerative disease association and particularly the RBD‐synucleinopathy association. Several issues relating to evolving concepts, controversies, and future directions are then reviewed, with an emphasis on idiopathic RBD representing an early feature of a neurodegenerative disease and particularly an evolving synucleinopathy. Planning for future therapies that impact patients with idiopathic RBD is reviewed in detail.

Subfields: Cognitive Neuroscience, Epidemiology, Neurology

View Paper: https://www.semanticscholar.org/paper/3cb1c8a0275f5a9f5827e8e80457e601e5a056dd

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In Cognitive Neuroscience

1. Brad Boeve
2. C. Schenck
3. M. Mahowald

In Epidemiology

1. Brad Boeve
2. C. Schenck
3. M. Mahowald

In Neurology

1. C. Schenck
2. M. Mahowald

Citations in the corpus

• Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series. (2013, background): “The broader associations of RBD and synucleinopathies, such as PD emerging prior to or concurrent with the emergence of RBD, and the almost 100% link of MSA with RBD, and approximately 50% link of PD with RBD, have also received considerable attention [33,34–40,41,42].”