Cartilage tissue remodeling in response to mechanical forces.

By Alan J. Grodzinsky, M. Levenston, Moonsoo M. Jin, E. Frank. Annual Review of Biomedical Engineering, 2000

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Mechanical compression drives cancer cells toward invasive phenotype (2011, background): “Despite extensive studies on the role of mechanical signals in many aspects of physiology, including endothelial function (9, 10), tissue maintenance (11, 12), and morphogenesis (13, 14), the role of mechano-stimulation in tumor biology is largely unexplored.”
Interstitial flow and its effects in soft tissues. (2007, background): “For example, for a simple noncompeting 1:1 binding reaction, Ri could take the following form: RMorphogen = −konCMorphCBS + koff CBS−Morph, (12) where kon and koff are rate constants specific for the morphogen/binding site pair, CMorph is the concentration of morphogen, CBS is the concentration of b”
Reinforcement of hydrogels using three-dimensionally printed microfibres (2015, positive): “For translational purposes, it is important to realize that native cartilage is exposed to 15–45% axial deformation under long-term static compression 49 .”