The emerging complexity of protein ubiquitination.

By D. Komander. Biochemical Society Transactions, 2009

835 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/1417d60f26c4215e068888d6fa170ce242a0c189

How researchers see this paper

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In Molecular Biology

1. Steven P. Gygi
2. R. Rad
3. M. Sowa
4. Edward L. Huttlin
5. J. Harper
6. John Rush
7. Jose M. Duarte
8. M. B. Metzger

In Oncology

1. J. Harper
2. Steven P. Gygi
3. A. Weissman
4. B. McConnell
5. Vincent W. Yang

Citations in the corpus

• RCSB Protein Data Bank: Enabling biomedical research and drug discovery (2019, background): “The UPS pathway is regulated by sequential action of three classes of activating enzymes: E1 (two human enzymes), E2 ( 40 human enzymes), and E3 (>600 human enzymes) (Figure 4a).(97) The end result of this combinatorial three-step enzyme cascade is an ubiquitinated substrate that is in turn recogniz”
• HECT and RING finger families of E3 ubiquitin ligases at a glance (2012, background): “Ubiquitylation occurs through the sequential action of three classes of protein: ubiquitinactivating enzymes (E1s), ubiquitinconjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs), and ubiquitin-protein ligases (E3s) (Komander, 2009).”
• Mammalian Krüppel-Like Factors in Health and Diseases (2010, background): “Polyubiquitination provides a signal for the degradation of substrate proteins by the 26S proteasomal complex, whereas monoubiquitination usually alters the activity of a protein (227).”
• Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences (2012, neutral): “…other lysine residues and mono-ubiquitination or multiple mono-ubiquitination are implicated in numerous regulatory processes, such as signal transduction, trafficking, DNA damage response, DNA repair, and autophagy (reviewed in Komander, 2009; Ikeda et al , 2010; and Behrends and Harper, 2011).”
• Systematic and quantitative assessment of the ubiquitin modified proteome (2011, positive): “K63-based signaling is likely occurring constitutively in cells without stimuli that are known to produce acute K63-linked polyubiquitylation of specific proteins (DNA damage, TNFα, and EGF) (Komander, 2009).”