Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

By K. Fassbender, M. Simons, C. Bergmann, M. Stroick, D. Lütjohann, P. Keller, H. Runz, Sandra Kühl, T. Bertsch, K. Bergmann and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,039 citations recorded by the source corpus.

Subfields: Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/3ef549f74d0f96e986f189fdd0757261b34cb620

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Physiology

In Surgery

Citations in the corpus

Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts (2003, background): “The � -site APP cleavage enzyme (BACE1) has been identified recently as a novel membrane-bound aspartyl-protease (De Strooper and Annaert, 2000; Esler and Wolfe, 2001 ) and cleaves APP in its luminal domain to generate a secreted ectodomain ( � APP).”
Alzheimer's disease: strategies for disease modification (2010, neutral): “Specifically, studies with HMG-CoA reductase inhibitors (statins”
Drug resistance in brain diseases and the role of drug efflux transporters (2005, background): “In addition, it has been proposed that the expression pattern of Pgp has a key role in the aetiology and pathogenesis of brain diseases such as Alzheimer's disease, Parkinson's disease and brain HIV infectio”
Pathways towards and away from Alzheimer's disease (2004, background): “Statin treatment decreases Aβ levels and plaque formation in APP mutant transgenic mic”
Linking Lipids to Alzheimer’s Disease: Cholesterol and Beyond (2011, background): “Tau phosphorylation by cdk5 and Fyn in response to amyloid peptide Aβ (25-35): involvement of lipid rafts.”