The growing impact of click chemistry on drug discovery.

By H. Kolb, K. Sharpless, The Scripps. Drug Discovery Today, 2003

2,615 citations recorded by the source corpus.

How researchers see this paper

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Cytocompatible Click-based Hydrogels with Dynamically-Tunable Properties Through Orthogonal Photoconjugation and Photocleavage Reactions (2011, background): “, the concept of click chemistry has been rapidly adopted by many disciplines, perhaps most notably in materials science, with annual publication numbers continuing to increase exponentiall”
Click Chemistry in Complex Mixtures: Bioorthogonal Bioconjugation (2014, background): “…powerful connecting reactions, describes the most specific bioorthogonal reactions that are wide in scope, easy to perform, and usually employ readily available reagents that are insensitive to oxygen and water (Kolb et al., 2001)(Hawker and Wooley, 2005; Kolb and Sharpless, 2003; Wu et al., 2004).”
Chemical remodelling of cell surfaces in living animals (2004, background): “Indeed, the azide has an alternative mode of reactivity, the 1,3-dipolar cycloaddition with alkynes, which has been used for bioconjugation reactions and could potentially be modified for use in vivo”