Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

By D. Bilder, Norbert Perrimon. Nature, 2000

745 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3e92e07dcc224e82aa6a409b27441821b23bad9b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Mary B. Kennedy
2. C. Gottardi
3. Andrew J. Ewald
4. F. Mantovani
5. Zena Werb
6. M. Egeblad
7. L. Banks

In Cellular and Molecular Neuroscience

1. Mary B. Kennedy
2. F. Mantovani
3. L. Banks

In Molecular Biology

1. Zena Werb
2. M. Egeblad
3. Andrew J. Ewald
4. C. Gottardi
5. F. Mantovani
6. Angela Jeanes
7. L. Banks
8. Alpha S. Yap

Citations in the corpus

• The Human Papillomavirus E6 protein and its contribution to malignant progression (2001, positive): “…tumour suppressor Scrib, which cooperates with Dlg and Lgl to control both formation of cell junctions and inhibition of epithelial cell growth, possibly through controlling the localization of growth factor receptors and signalling molecules (Bilder and Perrimon, 2000; Bilder et al., 2000).”
• Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice (2007, neutral): “Discs large (dlg) (Woods and Bryant, 1991), lethal giant larvae (lgl) (Gateff and Schneiderman, 1969), and scribble (scrib) (Bilder and Perrimon, 2000; Bilder et al., 2000) were originally identifi ed as tumor suppressor genes in Drosophila.”
• Tight junctions and cell polarity. (2006, background): “Although it is not clear if these proteins physically form a complex, studies in Drosophila demonstrate genetic interactions between these proteins (Bilder & Perrimon 2000, Bilder 2004).”
• Densin-180 Forms a Ternary Complex with the α-Subunit of Ca2+/Calmodulin-Dependent Protein Kinase II and α-Actinin (2001, background): “Other members of the LAP family, which include LET-413, scribble, and ERBIN (Bilder and Perrimon, 2000; Borg et al., 2000; Legouis et al., 2000), are associated with cell membranes at specialized domains.”
• Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, background): “scrib tumors, although not capable of forming secondary foci, share important characteristics with RasV12/scrib–/– tumors, including loss of cell polarity, tissue overgrowth (Bilder and Perrimon, 2000), and extensive disruption of the BM (supplementary material Fig.”
• Cadherins and cancer: how does cadherin dysfunction promote tumor progression? (2008, background): “They have also demonstrated functional interplay, by positive and negative feedback, between the different complexes to maintain their asymmetric localization within cells (Bilder and Perrimon, 2000; Benton and St Johnston, 2003; Tanentzapf and Tepass, 2003; Yamanaka et al., 2003).”