Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016.

By B. Xavier, C. Lammens, Rohit Ruhal, S. Kumar-Singh, P. Butaye, H. Goossens, S. Malhotra-Kumar. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2016

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We identified a novel plasmid-mediated colistin-resistance gene in porcine and bovine colistin-resistant Escherichia coli that did not contain mcr-1. The gene, termed mcr-2, a 1,617 bp phosphoethanolamine transferase harboured on an IncX4 plasmid, has 76.7% nucleotide identity to mcr-1. Prevalence of mcr-2 in porcine colistin-resistant E. coli (11/53) in Belgium was higher than that of mcr-1 (7/53). These data call for an immediate introduction of mcr-2 screening in ongoing molecular epidemiological surveillance of colistin-resistant Gram-negative pathogens.

Subfields: Infectious Diseases, Molecular Medicine, Oncology

View Paper: https://www.semanticscholar.org/paper/3d91dd09f87f4e700b63a30d86780275efd25efe

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In Infectious Diseases

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In Molecular Medicine

1. L. Poirel
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Citations in the corpus

• Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes (2017, background): “The corresponding samples were collected from many Asian countries (Cambodia, China, Japan, Laos, Malaysia, Taiwan, Singapore, and Vietnam) but also from Europe (Belgium, Denmark, France, Germany, Portugal, Italy, the Netherlands, Spain, Sweden, Switzerland, and the UK), the Americas (Argentina, Bra”