Polymyxins: Antibacterial Activity, Susceptibility Testing, and Resistance Mechanisms Encoded by Plasmids or Chromosomes

By L. Poirel, A. Jayol, P. Nordmann. Clinical Microbiology Reviews, 2017

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Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives (2021, background): “This causes leakage of cellular molecule and inhibition of cellular respiration [57].”
Antimicrobial Resistance in Escherichia coli (2018, background): “Production of MCR-1 in E. coli leads to a 4-to 8-fold increase in the MICs of polymyxins (232).”
Epidemiology and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Pseudomonas aeruginosa Infections (2019, background): “Initially, low doses of CMS were used in clinics, based on the manufacturer’s instructions (181–183), but thanks to more recent pharmacokinetic and pharmacodynamic (PK/PD) data from population studies, it is now possible to provide an update of recommended dosages (171, 172, 184, 185).”
Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019) (2020, background): “this process is independent on the uptake of colistin into the cell [1,8,11,13,16,23] (Figure 3).”
Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “Of particular concern among the Enterobacterales is the role that these plasmids continue to play in the emergence and dissemination of ESBLs, particularly those of the blaCTX-M type (19, 295, 296); AmpC-type cephalosporinases (blaCMY-2 and blaDHA-1) (297–299); carbapenemase-encoding genes (blaVIM, ”