Ceramide-orchestrated signalling in cancer cells

By Samy Morad, M. Cabot. 2012

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C24‐Ceramide Drives Gallbladder Cancer Progression Through Directly Targeting Phosphatidylinositol 5‐Phosphate 4‐Kinase Type‐2 Gamma to Facilitate Mammalian Target of Rapamycin Signaling Activation (2020, background): “(4-6) Growing evidence has established that altered ceramide metabolic pathways have been linked to tumorigenesis and therapeutic response in numerous cancers.(1,7) The biological functions of ceramides were thought to be chain-length specific and have been seldom investigated.”
Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “Furthermore, sphingolipids, such as ceramide or sphingosine-1-phosphate, eicosanoids (e.g. PGE2) and phosphoinositides have important signalling functions in cells and tissues (Morad and Cabot, 2013; Wymann and Schneiter, 2008).”