Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea: a cohort study during an epidemic in Quebec.

By J. Pépin, N. Saheb, M. Coulombe, M. Alary, Marie-Pier Corriveau, S. Authier, Michel Leblanc, G. Rivard, M. Bettez, Valérie Primeau and 3 more. Clinical Infectious Diseases, 2005

1,041 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Infectious Diseases, Surgery

View Paper: https://www.semanticscholar.org/paper/3d63a7d9d5a530dff68d8d655200c63c5ea77768

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Critical Care and Intensive Care Medicine

1. J. Bartlett
2. Victoria J. Fraser

In Infectious Diseases

1. J. Bartlett
2. Louis Valiquette
3. Benoît Cossette
4. J. Pépin
5. J. H. Morse

In Surgery

1. J. Bartlett

Citations in the corpus

• Clostridium difficile--associated disease in a setting of endemicity: identification of novel risk factors. (2007, result): “Other studies have been unable to confirm this finding [4, 25].”
• Narrative Review: The New Epidemic of Clostridium difficileAssociated Enteric Disease (2006, background): “The final factor is resistance in vitro to fluoroquinolones, which is infrequently observed in strains collected before 2001 and may be an important factor in the increased frequency of disease rather than contributing to its virulence (20, 66, 68, 77).”
• Emergence of Clostridium difficile-associated disease in North America and Europe. (2006, background): “Since March 2003, outbreaks of severe cases of CDAD have been reported in hospitals in Montreal and southern Quebec, with an increased risk of relapses [42–44].”
• Mortality attributable to nosocomial Clostridium difficile–associated disease during an epidemic caused by a hypervirulent strain in Quebec (2005, methodology): “Multiple hospital admissions for the same patient were considered to be a single “episode of care” if the interval between dates of discharge and subsequent readmissions was 60 days or less.(12) Hospital admissions separated by more than 60 days were considered to be distinct episodes of care.”
• The Changing Epidemiology of Clostridium difficile Infections (2010, background): “A retrospective study of all cases of CDI over a 13-year period in Quebec, Canada, reported an increase in incidence from 35.6 cases per 100,000 population in 1991 to 156.3 cases per 100,000 population in 2003 (152).”
• Development and Validation of a Clostridium difficile Infection Risk Prediction Model (2011, background): “Primary risk factors for CDI include receipt of antimicrobials, older age, high severity of illness, exposure to other patients with CDI, and receipt of gastric acid suppressants.(10-17) Despite the breadth and depth of knowledge about risk factors available in the medical literature, healthcare fac”
• Antibiotics and Bacterial Resistance in the 21st Century (2014, background): “Retapmulin (81) and the BC-3781 (82), a pleuromutilin in clinical development. figure 24.”
• Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). (2018, neutral): “e14 • CID 2018:66 (1 April) • McDonald et al certain classes—third-/fourth-generation cephalosporins [99], fluoroquinolones [36, 37, 100], carbapenems [99], and clin-”