Osteoarthritis cartilage histopathology: grading and staging.
By K. P. Pritzker, S. Jimenez, K. Ostergaard, J. Pelletier, P. Revell, Donald Salter, W. B. Berg. Osteoarthritis and Cartilage, 2006
2,300 citations recorded by the source corpus.
OBJECTIVE Current osteoarthritis (OA) histopathology assessment methods have difficulties in their utility for early disease, as well as their reproducibility and validity. Our objective was to devise a more useful method to assess OA histopathology that would have wide application for clinical and experimental OA assessment and would become recognized as the standard method. DESIGN An OARSI Working Group deliberated on principles, standards and features for an OA cartilage pathology assessment system. Using current knowledge of the pathophysiology of OA morphologic features, a proposed system was presented at OARSI 2000. Subsequently, this was widely circulated for comments amongst experts in OA pathology. RESULTS An OA cartilage pathology assessment system based on six grades, which reflect depth of the lesion and four stages reflecting extent of OA over the joint surface was developed. CONCLUSIONS The OARSI cartilage OA histopathology grading system appears consistent and simple to apply. Further studies are required to confirm the system's utility.
Subfields: Rheumatology
View Paper: https://www.semanticscholar.org/paper/3ce1b66207cad8f9797062074a48ef21dcb264a3
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In Rheumatology
Citations in the corpus
- Call for Standardized Definitions of Osteoarthritis and Risk Stratification for Clinical Trials and Clinical Use (2015, positive): “By histology, the abnormalities of OA include cartilage fibrillation, fissuring and denudation to bone, loss of proteoglycan, chondrocyte death or proliferation and osteophyte formation [36].”
- Knee osteoarthritis has doubled in prevalence since the mid-20th century (2017, background): “Eburnation is a sclerotic, ivory-like reaction of subchondral bone that occurs from bone-on-bone contact at sites exposed by advanced cartilage erosion (12, 21).”