Call for Standardized Definitions of Osteoarthritis and Risk Stratification for Clinical Trials and Clinical Use

By V. Kraus, F. Blanco, Martin Englund, M. Karsdal, L. Lohmander. Osteoarthritis and Cartilage, 2015

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Osteoarthritis is a heterogeneous disorder. The goals of this review are (1) To stimulate use of standardized nomenclature for osteoarthritis (OA) that could serve as building blocks for describing OA and defining OA phenotypes, in short to provide unifying disease concepts for a heterogeneous disorder; and (2) To stimulate establishment of ROAD (Risk of Osteoarthritis Development) and ROAP (Risk of Osteoarthritis Progression) tools analogous to the FRAX™ instrument for predicting risk of fracture in osteoporosis; and (3) To stimulate formulation of tools for identifying disease in its early preradiographic and/or molecular stages -- REDI (Reliable Early Disease Identification). Consensus around more sensitive and specific diagnostic criteria for OA could spur development of disease modifying therapies for this entity that has proved so recalcitrant to date. We fully acknowledge that as we move forward, we expect to develop more sophisticated definitions, terminology and tools.

Subfields: Pharmacology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/f41ee7ec1f8eaeb75740f660e4860f0c880a33f0