Graded persistent activity in entorhinal cortex neurons

By A. Egorov, Bassam N. Hamam, E. Fransen, Michael E. Hasselmo, A. Alonso. Nature, 2002

777 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3cbbbe33cc870e9a924c8d7a8c6318521caaed5b

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Citations in the corpus

Dendritic excitability and synaptic plasticity. (2008, neutral): “Indeed, positive-feedback loops in the activity-dependent regulation of intrinsic excitability have been found in neural systems as diverse as cerebellum (17, 35), neocortex (156, 727), entorhinal cortex (195), hippocampal CA1 region (854), and in hippocampal cell culture (234, 419).”
Dynamical principles in neuroscience (2006, background): “It is still unclear whether this bistability arises from intrinsic or circuit mechanisms or a combination of the two Egorov et al., 2002; Shu et al., 2003 . iii Both CPGs and cortical microcircuits demonstrate attractor dynamics and transient dynamics see, for example, Abeles et al. 1993 ; Ikegaya…”
Modes and Models of Forebrain Cholinergic Neuromodulation of Cognition (2010, background): “Persistent spiking seems to result from muscarinic receptor activation of a calcium-sensitive nonspecific cation current I(CAN) (Egorov et al, 2002; Shalinsky et al, 2002; Fransen et al, 2006).”
Long-term plasticity of intrinsic excitability: learning rules and mechanisms. (2003, background): “Such postsynaptic depolarization that elicit brief, high-frequency firing causes a long-term increase in intrinsic excitability in DCN neurons (Aizenman and Linden 2000) in visual cortical pyramidal neurons (Cudmore et al. 2001) and in entorhinal cortical neurons (Egorov et al. 2002).”
A Recurrent Network Mechanism of Time Integration in Perceptual Decisions (2006, background): “Moreover, other slow cellular processes, like calcium-dependent inward current (Egorov et al., 2002; Durstewitz, 2003; Major and Tank, 2004) or short-term synaptic plasticity (Abbott and Regehr, 2004) may contribute to time integration as well as persistent activity.”
The temporal context model in spatial navigation and relational learning: toward a common explanation of medial temporal lobe function across domains. (2005, methodology): “The existence of a stable firing rate in the absence of input observed by Egorov et al. (2002) provides the capability to implement this property. Further, Egorov et al. (2002) observed that these cells respond to subsequent suprathreshold inputs by adopting a new stable firing rate (see Figure 5).”
Entorhinal–hippocampal neuronal circuits bridge temporally discontiguous events (2015, background): “…depends on activation of the metabotropic glutamate receptor 1 (mGluR1) and cholinergic muscarinic www.learnmem.org 439 Learning & Memory receptors (Egorov et al. 2002; Yoshida et al. 2008; Jochems et al. 2013), cholinergic deafferentation in EC or local injection of a muscarinic receptor…”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, neutral): “, 2006; Wang, 1999) and entorhinal cortex (Egorov et al., 2002; Fransen et al., 2006).”