MicroRNAs as oncogenes and tumor suppressors.

By Chang‐Zheng Chen. New England Journal of Medicine, 2005

2,160 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c75c0493a55a9e892da39ed56af17e3b37c6f10

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Bing Lim
2. K. Rajewsky
3. Changchun Xiao
4. David Baltimore
5. D. Rao
6. Ryan M. O’Connell

In Molecular Biology

1. Changchun Xiao
2. Bing Lim
3. D. Calado
4. K. Rajewsky
5. H. Lodish
6. David Baltimore
7. Ryan M. O’Connell
8. D. Rao

Citations in the corpus

• Altered Expression of miR-21, miR-31, miR-143 and miR-145 Is Related to Clinicopathologic Features of Colorectal Cancer (2008, background): “Although the number of verified human miRNAs is still expanding, only few have been functionally described. However, emerging evidences suggest potential involvement of altered regulation of miRNA in the pathogenesis of cancers, and these genes are thought to function as both tumor suppressors and o”
• Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes (2008, background): “The miR-17-92 miRNA cluster is located at human chromosome 13q31 in a genomic region that is often amplified in lymphomas and other cancers, and cancer cells have high expression of the mature miRNA molecules encoded by this locu”
• MicroRNA control in the immune system: basic principles. (2009, background): “…13q31, a genomic region that is frequently amplified in lymphomas and solid tissue cancers, and the mature miRNAs encoded by this locus are expressed in high amounts in those cancer cells (Hayashita et al., 2005; Lu et al., 2005; Ota et al., 2004; Tagawa and Seto, 2005; Zhang et al., 2007).”
• MicroRNA-125b is a novel negative regulator of p53. (2009, background): “Differences in miRNA expression profiles define the signatures of various cancers, and miRNA dysregulation can lead to all the hallmarks of cancer (Garzon et al. 2006; Zhang et al. 2007). miRNAs are known to be both regulators and targets of oncogenes and tumor suppressor genes (Garzon et al. 2006).”