Dendrimer biocompatibility and toxicity.

By R. Duncan, L. Izzo. Advanced Drug Delivery Reviews, 2005

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Drug delivery and nanoparticles: Applications and hazards (2008, background): “A recent review on this topic (Duncan and Izzo 2005) concluded that it will only ever be possible to des-ignate a dendrimers as “safe” when related to a speciﬁ c application.”
Nanoparticles as drug delivery systems (2012, neutral): “also cause serious toxic effects [49].”
The effect of particle design on cellular internalization pathways (2008, background): “, microemulsions (5), dendrimers (6), immunoconjugates (7)], or the synthesis of carbon nanotubes (8) and inorganic particles (9).”
Smart Nanoparticles for Drug Delivery Application: Development of Versatile Nanocarrier Platforms in Biotechnology and Nanomedicine (2019, background): “Dendrimers are three-dimensional, hyperbranched nanoparticles, consisting of polymeric branching units covalently attached to a central core, organized in concentric layers (named generations) and that terminate with a number of external surface functional groups [100, 101] (Figure 9(a)).”
Removal of heavy metals and organic pollutants from water using dendritic polymers based adsorbents: A critical review (2018, background): “However, safe and efficacious dendrimers can only emerge from the rational chemical design supported by a clear understanding of biological rationale [93].”