Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema.

By N. Yamada, M. Yamaya, S. Okinaga, K. Nakayama, K. Sekizawa, S. Shibahara, H. Sasaki. American Journal of Human Genetics, 2000

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Pharmacological and Clinical Aspects of Heme Oxygenase (2008, neutral): “Yamada et al. (2000), in examining a (GT)n dinucleotide repeat in the 5 -flanking region of the human HO-1 gene, described the polymorphism of HO-1 and reported that the larger the size of the (GT)n repeat in the HO-1 gene promoter the greater the chance of reducing HO-1 inducibility by reactive…”
Heme oxygenase-1: from bench to bedside. (2005, background): “A microsatellite polymorphism in the promoter for HO-1 has been associated with the development of emphysema, and this polymorphism was shown to cause decreased promoter responsiveness to hydrogen peroxide in vitro (118).”
Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. (2003, background): “The number of (GT)n repeats determines the inducibility of this gene, such that Japanese male smokers with a short poly(GT)n polymorphism and a poorly inducible gene have a statistically higher incidence of emphysema than smokers with a long poly-(GT)n repeat and a better inducible gene [135].”
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications (2005, background): “, 1999b) and a polymorphic GT repeat region (Yamada et al., 2000).”