An Atomic Model of the Interferon-β Enhanceosome

By D. Panne, T. Maniatis, S. Harrison. 2007

502 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c5b0588417ca4f5dac4abd6be25bbf2f08730d4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Immunology

In Molecular Biology

Citations in the corpus

Transcription factors interact with RNA to regulate genes (2022, background): “TFs typically contain DNA-binding domains that recognize specific sequences and multiple TFs collectively bind to enhancers and promoter-proximal regions of genes (Avsec et al., 2021; Panne et al., 2007).”
Interferons at age 50: past, current and future impact on biomedicine (2007, methodology): “Transcriptional induction of IFN-β has been a model experimental system for defining interactions of transcription factors as an enhanceosome multiprotein complex with DN”
Epigenetic reprogramming and induced pluripotency (2009, background): “Alterations in DNA structure induced by the binding of multiple factors could also contribute to the specificity of their binding (Panne et al., 2007), explaining how Oct4 and Sox2 distinguish developmentally appropriate binding sites from those that carry the recognition motif but are irrelevant…”
Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. (2008, methodology): “In support of this model, IRF-7 can bind to the IFN-b promoter (Wathelet et al., 1998; Panne et al., 2007b) and can enhance transcription dramatically (Yang et al., 2004).”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “An atomic model for the complex of eight of these factors on the DNA has been constructed based on three crystal structures (Panne et al., 2007).”