Designing multifunctional quantum dots for bioimaging, detection, and drug delivery

By P. Zrazhevskiy, M. Sena, Xiaohu Gao. Chemical Society Reviews, 2010

920 citations recorded by the source corpus.

The emerging field of bionanotechnology aims at revolutionizing biomedical research and clinical practice via introduction of nanoparticle-based tools, expanding capabilities of existing investigative, diagnostic, and therapeutic techniques as well as creating novel instruments and approaches for addressing challenges faced by medicine. Quantum dots (QDs), semiconductor nanoparticles with unique photo-physical properties, have become one of the dominant classes of imaging probes as well as universal platforms for engineering of multifunctional nanodevices. Possessing versatile surface chemistry and superior optical features, QDs have found initial use in a variety of in vitro and in vivo applications. However, careful engineering of QD probes guided by application-specific design criteria is becoming increasingly important for successful transition of this technology from proof-of-concept studies towards real-life clinical applications. This review outlines the major design principles and criteria, from general ones to application-specific, governing the engineering of novel QD probes satisfying the increasing demands and requirements of nanomedicine and discusses the future directions of QD-focused bionanotechnology research (critical review, 201 references).

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3c137f17b1bd1dca5186927af2d9368461e95a90

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In Materials Chemistry

1. John V. Frangioni
2. Ali Khademhosseini
3. Moungi G. Bawendi
4. Hak Soo Choi
5. Edward H. Sargent

In Molecular Biology

1. Ali Khademhosseini
2. John V. Frangioni
3. Hak Soo Choi

Citations in the corpus

• Rapid Translocation of Nanoparticles from the Lung Airspaces to the Body (2010, background): “Nanoparticles have been proposed as diagnostic, therapeutic and theranostic agents for a wide variety of human disease”
• Biocompatibility of engineered nanoparticles for drug delivery. (2013, background): “Zrazhevskiy discussed about reducing long-term QDot toxicity [183].”
• Smart nanoparticles for cancer therapy (2023, background): “97 The tumor might be seen while the medicine is being released at the desired location using this nanoparticle.”
• Smart nanocarrier-based drug delivery systems for cancer therapy and toxicity studies: A review (2018, background): “Quantum dots [154], fluorescent semiconducting nanocarriers, are often made of hundreds to thousands of atoms of group II and group VI molecule and have unique photophysical properties [155].”